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CGD Policy Blogs

 

Setback for Malaria Vaccine: Time for an AMC?

There was bad news in research published yesterday in the New England Journal of Medicine about the effectiveness of what had seemed to be the best prospect for a malaria vaccine, known by the unsexy name of 'RTS,S'.

The study of the phase III trials finds that in babies (aged 6-12 weeks) the vaccine only reduces malaria by less than a third. This is disappointing because this is less than half the effectiveness that had been suggested by the phase II clinical trials.

Should UNITAID Rethink Its Raison d’Être?

UNITAID: maybe you’ve heard of it, or maybe not. Launched in 2006, UNITAID has lived in the shadow of its older and bigger global-health siblings (the Global Fund, GAVI, and PEPFAR, to name a few). Perhaps due to its relative obscurity and late entry to a crowded global-health field, UNITAID has proactively worked to differentiate itself through a focus on commodities, market shaping, novel funding sources, and innovation. To wit, UNITAID’s stated mission is “to contribute to scale up access to treatment for HIV/AIDS, malaria and tuberculosis for the people in developing countries by leveraging price reductions of quality drugs and diagnostics, which currently are unaffordable for most developing countries, and to accelerate the pace at which they are made available.”

Our New Year’s Resolution: Better, Faster, Cheaper Clinical Trials for the World’s Poorest

Technology is not the answer to all the world’s problems, but advances in medical diagnostics and therapeutics have the potential to improve the lives of millions of the world’s poorest people who suffer from diseases that have few, if any, effective treatments. While recent efforts by product development partnerships (PDPs) and donors like the Bill & Melinda Gates Foundation and the National Institutes of Health have made tremendous progress in building a pipeline for health products for neglected diseases, we have a long way to go before many of these life-saving therapies reach patients.

Making the Case for Healthier Hearts in the Developing World

This is a joint post with Katherine Douglas.

I’d be willing to bet that nary a H8 meeting (if you have to ask….) has included a discussion on the impact of heart disease, obesity, or diabetes in developing countries. Yet chronic diseases, particularly cardiovascular disease (CVD), have emerged as a significant—and growing—threat to those living in poor countries.

Yesterday, the U.S. Institute of Medicine released an early version of a report entitled Promoting Cardiovascular Health in the Developing World: A Critical Challenge to Achieve Global Health. The report details governments, global health institutions, and development agencies’ lack of attention to CVD and offers recommendations to better prevent and control the disease.

FDA Goes Global: A New Approach to Food and Drug Import Safety

Last week, I participated in an event at the Center for Strategic and International Studies (CSIS) in which U.S. Food and Drug Administration (FDA) Commissioner Margaret Hamburg announced a remarkable shift in the FDA’s thinking on food and drug import safety. If adequately supported by Congress and translated into concrete action, this change in strategy on food and drug safety could have significant benefits for U.S. and global health and development.

A Public Health Time Bomb

There’s a lot of attention being paid to the counterfeit drug trade at the moment. Former President of France, Jacques Chirac, recently chaired a meeting with West African leaders to discuss how to crack down on counterfeiting. Meanwhile, the Wellcome Trust and the American Pharmaceutical Group held an Opinion Formers' conference on counterfeit medicines (presentations here); the International Federation of Pharmaceutical Manufacturers and Associations produced a brief on the issue; and Roger Bate has continued to draw attention to counterfeits and other drug quality issues in developing countries, including through his book Making a Killing. And this is all on top of the WHO-hosted IMPACT initiative on counterfeits, which started in 2006.

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