Together with some of the country’s leading experts, we explore how a new partnership between the U.S. Treasury Department and PEPFAR will support finance ministries to strengthen the efficiency and effectiveness of the health sector and the fight to end HIV/AIDS. This interactive discussion addresses several questions: Why this partnership? How can Treasury support the global health and HIV agenda? What challenges do finance ministries currently face in their engagement in the health sector? And how do we ensure that finance ministries are integrated into structures to monitor resources and expenditures in HIV and the health sector more broadly?