August 2010


Dear Colleague,

Just a month following release of the Drug Resistance Working Group’s report, I am happy to say that our recommendations are moving forward. I describe some of the early progress below in the monthly column.

There has been plenty of drug resistance news this summer – some of it good, but most of it alarming. I am certain you are thinking about the ramifications of the NDM – 1 gene that confers resistance to almost all antibiotics and can be easily transmitted between bacteria, reported in the recent Lancet Infectious Diseases article. The superbug has been traced to several developing countries with attendant and unhelpful finger-pointing and backlash. It once again highlights the urgent need for a global system to identify and report on resistant strains. As we recommend in the CGD Working Group report, a good start would be clearer and more aggressive use of the International Health Regulations to encourage local and national health authorities to be alert and responsive to drug resistance, not just the international movement of a small group of disease strains. To date, the superbug has been found in countries with strong surveillance systems, such as Australia, Canada, the U.S., the Netherlands and Sweden. How can we be sure of the magnitude of this problem or of other resistant bugs in countries with inadequate systems in place? 

In other news, the XVIIIth International AIDS Conference was held in Vienna last month. According to CGD colleagues that attended the conference, concern about growing ARV resistance was a dominant thread of conversation in the hallways. Thanks to the successful CAPRISA trial for HIV/AIDS prevention using a Tenofivir-based microbicide gel, there was much discussion about how resistance to the drug might be affected. Further evidence highlighting the need for more in-depth patient-provider interaction about adherence to HIV medicines and avoidance of HIV drug resistance was also presented at the Conference. It’s good news when an important AIDS breakthrough can also bring greater attention and scientific resources to look at drug resistance. See my colleague, Nandini Oomman’s, blog for more about the Conference.

As always, we welcome your thoughts at [email protected].

Regards,

Rachel Nugent
Deputy Director for Global Health
Center for Global Development

Turning Recommendations into Reality: CGD’s Impact on Drug Resistance Beginning to Take Shape

By Rachel Nugent

Since most readers of this newsletter are dedicated advocates of a stronger global response to drug resistance, you are well aware that efforts to curb resistance thus far have fallen woefully short. Across the spectrum – from R&D to supply chain, to patient adherence to drug resistance surveillance and lab capacity – people are making choices that increase the risk of stimulating or spreading drug resistance. Sometimes the implications are unknown, and sometimes they are simply ignored.

READ MORE

Latest drug resistance research

Drug Resistance in the news

Bacteria (besides TB)
TB
Malaria
HIV
Other

WORKING GROUP UPDATE

Read an editorial by DRWG member Iruka Okeke and chair Rachel Nugent: “When medicines fail: recommendations for curbing antibiotic resistance” J Infect Dev Ctries

RECENT / UPCOMING Events

  • Uppsala University/ReAct - Action on Antibiotic Resistance is hosting a conference – "The Global Need for Effective Antibiotics - Moving towards Concerted Action" – on September 6-8, 2010 in Uppsala, Sweden. Although the conference is invitation only, some sessions will be webcasted. You can read more about the conference on ReAct’s website.
  • The International Society of Chemotherapy will host a symposium on 30 August from 16:00-18:00 at the IPCAN-IFIC Congress in Cape Town (28 August-1 September). Participants will exchange ideas for activities to be undertaken by the recently created ISC Sub-Saharan Antimicrobial Stewardship network, such as developing educational tools, creating discussion forums on the ISC website and conducting studies on antimicrobial issues. For more information, please contact Jim Hutchinson or Gabriel Levy Hara (ISC Antimicrobial Stewardship Working Group co-chairs) or Ian Gould (Secretary General, ISC).
  • Submit a late-breaker abstract by September 8 to the 59th ASTMH meeting, November 3-10, 2010 in Atlanta
  • View abstracts and presentations from the June 2010 International HIV and Hepatitis Virus Drug Resistance Workshop
  • Peruse presentations from the 2010 Global Health Council conference, including a presentation of the CGD Working Group’s report
  • Consider participating in the 5th South African HIV Drug Resistance and Treatment Monitoring Workshop, University of the Free State, October 27-29, 2010 in Bloemfontein, South Africa
  • CGD at React conference

    CGD will sponsor a side event at the September 6-8 ReACT Conference in Uppsala on “The Global Need for Effective Antibiotics - Moving Towards Concerted Action.” The meeting will bring together potential partners in a Global Partnership to Improve Medicines Prescribing, Dispensing and Use for a discussion on modalities and objectives of the Global Partnership. Please email and let us know if you will be in Uppsala and are interested in attending this organizing meeting.

    CALL FOR PAPERS

    Download a preliminary announcement for the Third International Conference on Improving Use of Medicines (ICIUM 2011), April 10-14, 2011 in Alexandria, Egypt

    Partner resources

  • The U.S. Department of Health and Human Services held a stakeholder listening session on the Trans-Atlantic Task Force on AMR – see details here and visit the Task Force website here
  • Read testimonies from the US House of Representatives’ Subcommittee on Energy and Commerce hearing on Antibiotics and Animals
  • Read recently-issued US Food and Drug Regulatory Agency draft guidance on the Judicious Use of Medically Important Antimicrobials in Food-Producing Animals.  Press release; New York Times commentary
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