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Faced with many urgent challenges, the next U.S. president may be tempted to let global health issues bubble along on the back burner and simply allow reasonably well-funded programs that garner bipartisan support to continue unchanged. This would be a mistake. Instead, the president should set an ambitious course to improve global health by leveraging the full range of U.S. assets to create a more just and safe world. CGD vice president Ruth Levine shows the way.