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This paper discusses the role for policy integration to speed progress towards delivering the Sustainable Development Goals (SDGs). This is required because the goals set very ambitious targets for progress across a range of interlinked areas, encompassing both synergies and tradeoffs. Lessons of policy integration at the national level suggest that it is usually at best partially successful, requiring significant commitment from the highest levels of government. Policy integration regarding foreign affairs has proven even more challenging. This paper suggests a mechanism for prioritizing coordination and the use of coordination tools including regulation, safeguards, taxes, and subsidies. It also suggests re-orienting ministerial responsibilities where possible from input control to achievement of outcomes as well as tools to promote innovation by subnational governments and the private sector.